Any damage inflicted to the nervous system’s fibers, nerve cells, and the surrounding tissues can lead to peripheral neuropathy. The damage may be caused by infection, diabetes, metabolic trouble, or any traumatic injury. Peripheral neuropathy can result to the weak signal transmission between the brain and other parts of the body. This article will tackle how cannabinoids can help people suffering from neuropathic pain.
Neuropathic pain brought about by chemotherapeutic treatment, diabetes, herpes zoster, human immunodeficiency virus (HIV), nerve injury, and multiple sclerosis have all been considered to benefit from tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabidiol is a non-psychoactive cannabinoid in hemp plants and it is also known to have medicinal properties.
One of the known effective treatments to neuropathic pain is cannabidiol. It is extracted from cannabinoid-rich hemp plants. Although hemp plant itself is considered to be illegal by the law, there are many states that consider cannabidiol as a legal form of medication. Many patients who have tried using it firsthand claimed that it helped them with the relief of inflammation and pain, both conditions which are associated with peripheral neuropathy.
Neuropathic Pain and CBD Cannabidiol
Numerous clinical trials have been conducted on humans, using both oral and smoke cannabinoids. However, clinical trials using smoke cannabis lack well-implemented and placebo-controlled tests. A recent test conducted by the Canadian Medical Association Journal only managed to employ 32 test subjects. The test made use of smoke cannabis and followed a crossover randomized design. This was perhaps one of the well-designed smoked cannabis studies conducted. Unfortunately, the organization failed to enroll at least 32 patients, the number of test subjects needed to achieve a power of 80%.
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In a study conducted in 2007, it has been shown that a combination of CBD, terpenes (aromatic compounds found also in the marijuana plant), and THC have great efficacy in treating neuropathic pain brought about by peripheral neuropathy. The said study was conducted with the help of 125 patients. For patients suffering from multiple sclerosis, a cannabinoid-based medicine was found to reduce the level of spasticity. Moreover, cannabinoid has not only been evaluated for the treatment of neuropathic pain, but also for other illnesses such as chemotherapy-induced nausea and dementia. Several studies have also pointed out the efficiency of cannabinoid in treating psychiatric illnesses.
Many studies have already pointed out the efficiency of cannabinoids in treating various illnesses. However, there is no sufficient information yet to solidify the claim. Nonetheless, many medical experts continue to conduct studies in order to help exploit its value in the medical industry.
Cannabidiol Research: Neuropathic Pain
- Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain
- Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain
- Cannabis, pain, and sleep: Sativex Clinical Trials
- Sativex successfully treats neuropathic pain characterised by allodynia: clinical trial
- Cannabinoids for neuropathic pain
- Neuropathic orofacial pain: Cannabinoids as a therapeutic avenue
- Oromucosal delta9-THC/CBD for neuropathic pain associated with multiple sclerosis
- The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
- Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
- Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
- Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain
- Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action
- Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
- Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes
- Cannabinoids in the management of difficult to treat pain
- Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
- Marijuana extract helps prevent chemo pain
- Pot users less likely to take painkillers
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