CBD possesses natural anti-inflammatory features including anti-oxidants that prevent aging effects. Aging triggers degenerative diseases and affect a person’s health. Degenerative factors include changing bone composition and degenerating tissues.
There are many kinds of inflammation that are relieved by the anti-inflammatory properties of Cannabidiol. It is very effective in the treatment of Rheumatoid arthritis and other pains of the joints. Aside from relieving pains, it is also known to be effective in curing and reversing the symptoms.
Inflammation is part of the body’s immune system and is part of the natural healing process. Inflammation has several benefits which involve delivering necessary defenses to the site of injury, such as activating the immune system and increasing the temperature.
There are five classical signs of inflammation: pain, heat, redness, swelling, and loss of function. Inflammation may be acute or chronic. Acute inflammation occurs during sudden injury such as a viral infection and fractures. Chronic inflammation, on the other hand, happens when the body fails to halt the immune response which leads to misdirected immune response. Anti-inflammatory drugs are one of the well-studied drugs nowadays.
CBD and Inflammation
Cannabidiol can be used to treat a number of symptoms including inflammation. Phyto-cannabinoids refer to cannabinoids that are naturally occurring in the cannabis plant while cannabinoids are the compounds that stimulate the endocannabinoid system. The endocannabinoid system consists of two known receptors — CB1 which is actively expressed in the brain and CB2 which is predominant in the immune system. Cannabidiol is the main component of hemp oil which is extracted from the cannabis plant. Moreover, hemp oils do not contain THC or tetrahydrocannabinoid which is a psychoactive compound.
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Inflammation is said to be the primary cause of pain during injury. Cannabinoids aid in reducing pain by stimulating the cannabinoid receptors which also mediate pain.
Cannabidiol or CBD is currently being widely studied as a potential cure for different inflammatory disorders such as intestinal inflammation, neuroinflammation, inflammatory lung disease, and more. Several researches show that cannabinoids have anti-inflammatory effects. Studies also show that cannabinoids suppress cytokine production. Cytokines modulate and regulate the immune response. Suppression of cytokines indicates that cannabinoids thus have anti-inflammatory properties. In addition, CBD down regulates the NFkB pathway, a signalling pathway that promotes the expression of pro-inflammatory molecules.
In addition, hemp oils are rich in omega-3 and omega-6 fatty acids which have very strong anti-inflammatory properties. The gamma linolenic acid found in hemp oils is metabolized into dihomogamma-linolenic acid which inhibits the production of substances that would promote inflammation. Moreover, it is believed that dihomogamma-linolenic acid inhibits interleukin-1 which is needed for white blood cell communication. Thus, immune response is limited as well.
Hemp oils also contain terpenes which are aromatic molecules. Terpenes also have anti-inflammatory, anti-bacterial, and anti-viral properties.
As mentioned earlier, hemp oils do not contain THC which is the compound that gets an individual “high.” Hemp oil is suggested to be taken daily — about two tablespoons — for it to be effective in treating inflammation.
Cannabidiol Research: Inflammation
- Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
- The endocannabinoid system: an emerging key player in inflammation
- Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice
- Cannabinoids, endocannabinoids, and related analogs in inflammation
- Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor
- Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
- Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
- Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
- Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement
- Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
- Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
- Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death
- Cannabinoids in clinical practice
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